Drs. Altschuler and Wu

Math Matters at the Project ALS CORE

The key to finding better drugs at the Project ALS Therapeutics Core at Columbia (THE CORE) is developing better pre-clinical laboratory models of ALS. A range of models that actually reflect the human disease and capture the complexity of ALS …
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MEET THE CORE: SUSAN BRENNER-MORTON

MEET THE CORE: SUSAN BRENNER-MORTON Susan Brenner-Morton is an antibody expert who has spent decades developing these specialized tools to help us understand how motor neurons function normally—and dysfunction in ALS. We sat down virtually with Susan, who is Director …
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Prosetin Receives Orphan Drug Designation

Earlier this month, we reached a big regulatory milestone: Prosetin received Orphan Drug Designation, or orphan status, for the treatment of ALS from the Food and Drug Administration (FDA). Here, we break down what orphan status means, why it’s important, …
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ALS Research Lab

Improving Pharmacokinetic Properties of Promising Compounds

In our biweekly webinars, we have described the process of developing Prosetin—the first potential investigational drug to emerge from The Project ALS Therapeutics Core at Columbia (THE CORE)—in detail. A collaborative team led by Drs. Emily Lowry, Pieter Bos, Brent …
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The Wasserman Family

One Family’s Passionate Fight Against Neurodegenerative Diseases

The Wasserman family has experienced first-hand the devastating effects of neurodegenerative diseases: Sandra Wasserman lost her beloved husband to Parkinson’s disease, and her son to glioblastoma. Now in her eighties, Sandra has friends experiencing the debilitating consequences of Alzheimer’s disease …
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COVID-19 UPDATE FROM THE CORE

Last year, Project ALS launched The Project ALS Therapeutics Core at Columbia (THE CORE), a 3-year, $6.3M initiative toward the first meaningful therapies for ALS. Led by scientific co-directors Hynek Wichterle, PhD, Neil Shneider, MD, PhD, and Serge Przedborski, MD, …
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ALS patients, caregivers, and advocates with Senators Mike Braun and Lisa Murkowski at the 2020 More Than Our Stories advocacy conference.

Project ALS Endorses New ALS Legislation

Project ALS is encouraged by the introduction of two bills that aim to provide people with ALS faster, more robust access to experimental therapies. These bills are significant for specific, substantive reasons detailed below. Perhaps as importantly, they represent a …
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A COVID-19 Research Update

Dear Friends, Project ALS is acutely aware of the unimaginable circumstances that Americans and people around the world are now facing. Our hearts, souls, and minds are heavy with the dire situation that ALS patients, family members, and loved ones …
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