Suggested Publications
Project A.L.S.™-funded scientists publish the results of their experiments in foremost peer-reviewed journals, including Cell, Science, Neuron, Nature, and the Journal of Neuroscience. Publication in prestigious journals insures that Project A.L.S.™-supported science is being scrutinized and validated by leaders in the field of neuroscience. Publication is also a means by which Project A.L.S.™ research teams discover exciting new ideas.
Important publications based on Project A.L.S.™-driven science are featured here. Click on title to see abstract for a brief summary of the paper, or on "read full story" for complete text.
SELECTED PUBLICATIONS
November 12 2011
Amyotrophic Lateral Sclerosis
Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis.
vanBlitterswijk M, Gulati S, Smoot E, Jaffa M, Maher N, Hyman BT, Ivinson AJ, Scherzer CR, Schoenfeld DA, Cudkowicz ME, Brown RH Jr, Bosco DA.
November 3 2011
Neuron
Motor neurons and the sense of place.
Jessell TM, Sürmeli G, Kelly JS.
November 2011
Annual Review of Neuroscience
Motor neuron diversity in development and disease.
Kanning KC, Kaplan A, Henderson CE.
September 2011
Cell Stem Cell
Conversion of mouse and human fibroblasts into functional spinal motor neurons.
Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K.
August 10 2011
Nature Biotechnology
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.
Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L, Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M, Eagle A, Kammesheidt A, Christensen A, Mendell JR, Burghes AH, Kaspar BK.
May 26 2011
Neuron
Constructing and deconstructing stem cell models of neurological disease.
Han SS, Williams LA, Eggan KC.
February 04 2011
Cell
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.
Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A.
February 03 2011
Nature Biotechnology
A functionally characterized test set of human induced pluripotent stem cells.
Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K.
November 13 2010
Nat Neurosci
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.
Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH Jr.
November 01 2010
Human Molecular Genetics
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.
Bosco DA, Lemay N, Ko HK, Zhou H, Burke C, Kwiatkowski TJ Jr, Sapp P, McKenna-Yasek D, Brown RH Jr, Hayward LJ.
October 09 2010
Lancet Neurology
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
Shatunov A, Mok K, Newhouse S, Weale ME, Smith B, Vance C, Johnson L, Veldink JH, van Es MA, van den Berg LH, Robberecht W, Van Damme P, Hardiman O, Farmer AE, Lewis CM, Butler AW, Abel O, Andersen PM, Fogh I, Silani V, Chiò A, Traynor BJ, Melki J, Meininger V, Landers JE, McGuffin P, Glass JD, Pall H, Leigh PN, Hardy J, Brown RH Jr, Powell JF, Orrell RW, Morrison KE, Shaw PJ, Shaw CE, Al-Chalabi A.
September 09 2010
Neuron
Global control of motor neuron topography mediated by the repressive actions of a single hox gene.
Jung H, Lacombe J, Mazzoni EO, Liem KF Jr, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS.
September 03 2010
Cell Stem Cell
Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation.
Peljto M, Dasen JS, Mazzoni EO, Jessell TM, Wichterle H.
July 13 2010
Nature Neuroscience
What can pluripotent stem cells teach us about neurodegenerative diseases?
Wichterle H, Przedborski S..
2009
Current Topics in Developmental Biology
Hox networks and the origins of motor neuron diversity.
Dasen JS, Jessell TM.
July 25 2009
Cell
Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.
Dasen JS, De Camilli A, Wang B, Tucker PW, Jessell TM.
December 2009
Neuron
A cluster of cholinergic premotor interneurons modulates mouse locomotor activity.
Zagoraiou L, Akay T, Martin JF, Brownstone RM, Jessell TM, Miles GB
February 27 2009
Science
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.
July 31 2008
Science
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.
Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K.
July 25 2008
Cell
Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.
Dasen JS, De Camilli A, Wang B, Tucker PW, Jessell TM
April 15 2007
Nature Neuroscience
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.
Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S
March 22 2006
J Neuroscience
Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons.
Soundararajan P, Miles GB, Rubin LL, Brownstone RM, Rafuse VF
September 8 2004
J Neuroscience
Functional properties of motoneurons derived from mouse embryonic stem cells.
Miles GB, Yohn DC, Wichterle H, Jessell TM, Rafuse VF, Brownstone RM
August 8 2003
Science
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.
Kaspar BK, Lladó J, Sherkat N, Rothstein JD, Gage FH
June 15 2003
J Neuroscience
Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.
Kerr DA, Lladó J, Shamblott MJ, Maragakis NJ, Irani DN, Crawford TO, Krishnan C, Dike S, Gearhart JD, Rothstein JD
August 9 2002
Cell
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle H, Lieberam I, Porter JA, Jessell TM
