In 1998, Project ALS set the new paradigm for ALS research. This business model, now widely adopted, has accelerated the pace of research.
Project ALS opened the Jenifer Estess Stem Cell Laboratory, the world’s first privately funded laboratory to focus exclusively on the study of stem cells in ALS.
The lab recruited stem cell experts from leading institutions to work together to create better stem cell models of ALS.
The Project ALS team developed iPS technology—or ALS in a Dish—the first ever laboratory model of human ALS.
Scientists around the world are now using ALS in a Dish to screen for drugs that might slow or stop ALS. The Project ALS team is working to improve ALS in a Dish to be more accurate and reliable.
We may be able to slow down ALS by reducing neuro-inflammation.
Project ALS has identified new therapeutic targets for neuro-inflammation…
and is partnering with leading pharmaceutical companies to test anti-inflammatory drugs originally designed to treat cancers and other illnesses.
The Project ALS team is focused on getting these drugs across the brain-blood-barrier.
ALS destroys brain cells called motor neurons, which control most of our voluntary muscle movements.
Yet, motor neurons that control eye movements are resistant to the disease.
Project ALS has identified genetic differences between affected and unaffected motor neurons in ALS.
…The goal now is to make all motor neurons as resistant to ALS as motor neurons controlling eye movements.
From a patient blood sample…
...Project ALS researchers are able to screen for lipids and other possible markers of ALS…
…that may lead to earlier, more accurate diagnosis—and, ultimately, earlier therapeutic intervention.
Researchers have identified more than 30 genes involved in ALS.
The Project ALS team is developing technologies to edit, even silence ALS genes.
We have developed a technique called gene silencing that is nearing human trial.
Because ALS is considered a disease of brain cells called motor neurons, historically, research has focused on this one specific cell type.
Project ALS researches motor neurons unto themselves, but also in the context of related cell types, neural circuits, and the whole brain.
For example, what is the relationship between motor neurons, and brain cells called glia and interneurons?
Project ALS has invested in a deeper understanding of brain development. The more we learn about the developing brain, the better equipped we will be to intervene when something goes wrong.
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WOMEN & THE BRAIN